PLD2

Across TCGA cell cohorts, PLD2 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLD2-associated genes across cancer lineages are PCDH11Y, OR10T2, and PABPC1L2B. Each is linked with PLD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD2-to-partner and partner-to-PLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by PLD2-low versus PLD2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD2→partner) and Y-score (partner→PLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	2
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	2
SKIN	PABPC1L2B →	+0.013	+3.688	<.001	.002	3	2
BLOOD_Leukemia	FOXS1 →	+0.050	+3.949	.004	.002	3	2
BLOOD_Leukemia	SOX1 →	+0.407	+4.564	<.001	.001	3	2
BLOOD_Leukemia	SMIM32 →	+0.020	+3.584	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

PCDH11Y by PLD2 expression — URINARY_TRACT

Explore this box plot interactively →