PLCXD3

Across TCGA patient cohorts, PLCXD3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCXD3-associated genes across cancer lineages are p21, TIGAR, and Di-Ras3. Each is linked with PLCXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCXD3-to-partner and partner-to-PLCXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by PLCXD3-low versus PLCXD3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD3→partner) and Y-score (partner→PLCXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p21 →	+0.396	+3.009	.035	.019	3	2
LUSC	TIGAR →	+0.174	+3.045	.017	.018	3	2
UCEC	Di-Ras3 →	-0.179	-2.169	.001	.003	3	2
UCEC	14-3-3_beta →	-0.087	-2.295	.020	.033	3	2
UCEC	eEF2 →	+0.466	+3.700	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.255	-3.321	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p21 by PLCXD3 expression — LUSC

Explore this box plot interactively →