PLCXD3

Across TCGA cell cohorts, PLCXD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,080 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLCXD3-associated GO terms across cancer lineages are Cellular response to external stimulus, Regulation of substrate-dependent cell migration, cell attachment to substrate, and Positive regulation of substrate-dependent cell migration, cell attachment to substrate. Each is linked with PLCXD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLCXD3-to-partner and partner-to-PLCXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to external stimulus grouped by PLCXD3-low versus PLCXD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD3→partner) and Y-score (partner→PLCXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to external stimulus →	-0.078	-1.036	.001	.002	3	4
URINARY_TRACT	Regulation of substrate-dependent cell migration, cell attachment to substrate →	+0.178	+2.011	<.001	<.001	3	4
URINARY_TRACT	Positive regulation of substrate-dependent cell migration, cell attachment to substrate →	+0.178	+2.011	<.001	<.001	3	4
URINARY_TRACT	Positive regulation of leukocyte adhesion to arterial endothelial cell →	+1.025	+1.604	.004	.001	3	4
SKIN	Apoptotic cell clearance →	+0.141	+0.204	<.001	.004	3	4
URINARY_TRACT	Negative regulation of interleukin-5 production →	+0.442	+1.920	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

Cellular response to external stimulus by PLCXD3 expression — BONE

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