PLCXD3

Across TCGA cell cohorts, PLCXD3 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLCXD3-associated genes across cancer lineages are ZNF175, PLPPR2, and RSPH4A. Each is linked with PLCXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCXD3-to-partner and partner-to-PLCXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF175 grouped by PLCXD3-low versus PLCXD3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD3→partner) and Y-score (partner→PLCXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF175 →	-0.718	-3.321	<.001	.003	3	1
SKIN	PLPPR2 →	-0.993	-3.169	.005	.009	3	1
SKIN	RSPH4A →	-0.119	-3.369	<.001	.001	3	1
SKIN	GBE1 →	-0.853	-3.541	.001	.001	3	1
SKIN	MOB3B →	+1.042	+2.502	.002	.005	3	1
SKIN	ZNF45 →	-0.729	-3.190	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ZNF175 by PLCXD3 expression — SKIN

Explore this box plot interactively →