PLCXD2

Across TCGA patient cohorts, PLCXD2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCXD2-associated genes across cancer lineages are VEGFR2, ATM, and eEF2. Each is linked with PLCXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCXD2-to-partner and partner-to-PLCXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by PLCXD2-low versus PLCXD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD2→partner) and Y-score (partner→PLCXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.267	+1.820	.029	.016	3	2
UCEC	ATM →	-0.711	-2.321	<.001	.006	3	2
UCEC	eEF2 →	+0.365	+1.807	.013	.027	3	1
UCEC	EGFR_pY1068 →	-0.348	-3.000	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.121	-3.169	.014	.019	3	1
UCEC	ERK2 →	+0.276	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

VEGFR2 by PLCXD2 expression — UCEC

Explore this box plot interactively →