PLCXD2

Across TCGA cell cohorts, PLCXD2 mutation is significantly associated with the mutation status of many other genes, with 2,379 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCXD2-associated genes across cancer lineages are ZNF724, ZNF536, and GRIN3A. Each is linked with PLCXD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCXD2-to-partner and partner-to-PLCXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF724 grouped by PLCXD2-low versus PLCXD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD2→partner) and Y-score (partner→PLCXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF724 →	+2.893	+3.222	.003	.003	1	3
LARGE_INTESTINE	ZNF536 →	+1.478	+3.408	.007	.007	1	3
UPPER_AERODIGESTIVE_TRACT	GRIN3A →	+4.392	+4.954	.008	.008	1	3
BLOOD_Lymphoma	CROCC →	+2.969	+3.337	.009	.009	1	3
BLOOD_Lymphoma	LRP6 →	+4.969	+4.969	<.001	<.001	1	3
BLOOD_Lymphoma	STK4 →	+4.969	+4.014	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,379 associations by consensus.

ZNF724 by PLCXD2 expression — LARGE_INTESTINE

Explore this box plot interactively →