PLCXD1

Across TCGA patient cohorts, PLCXD1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCXD1-associated genes across cancer lineages are eIF4E, MEK1, and p62 Lck ligand. Each is linked with PLCXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCXD1-to-partner and partner-to-PLCXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PLCXD1-low versus PLCXD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD1→partner) and Y-score (partner→PLCXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.224	+2.584	.022	.011	3	1
UCEC	MEK1 →	+0.633	+3.700	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.715	+3.594	<.001	.001	3	1
UCEC	Akt_pT308 →	+0.798	+2.321	.006	.033	3	1
UCEC	PRAS40_pT246 →	+0.208	+2.598	.009	.006	3	1
UCEC	SF2 →	-0.119	-2.990	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eIF4E by PLCXD1 expression — UCEC

Explore this box plot interactively →