PLCXD1

Across TCGA cell cohorts, PLCXD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,757 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLCXD1-associated GO terms across cancer lineages are DNA replication proofreading, DNA strand elongation involved in DNA replication, and Constitutive heterochromatin formation. Each is linked with PLCXD1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PLCXD1-to-partner and partner-to-PLCXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by PLCXD1-low versus PLCXD1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD1→partner) and Y-score (partner→PLCXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication proofreading →	+0.168	+1.629	<.001	<.001	3	14
BONE	DNA strand elongation involved in DNA replication →	+0.171	+1.587	<.001	<.001	3	13
BONE	Constitutive heterochromatin formation →	+0.094	+1.655	.002	.002	3	13
BONE	DNA strand elongation →	+0.166	+1.663	.001	.001	3	13
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.183	+1.784	.001	.007	3	12
BONE	Meiotic chromosome condensation →	+0.214	+2.024	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,757 associations by consensus.

DNA replication proofreading by PLCXD1 expression — BONE

Explore this box plot interactively →