PLCL2

Across TCGA cell cohorts, PLCL2 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCL2-associated genes across cancer lineages are PAX1, GALP, and GPX6. Each is linked with PLCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCL2-to-partner and partner-to-PLCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX1 grouped by PLCL2-low versus PLCL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCL2→partner) and Y-score (partner→PLCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PAX1 →	+0.025	+4.060	.002	.003	3	2
LUNG_NSCLC_LUSC	GALP →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	GPX6 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MINDY4B →	+0.060	+4.643	<.001	.008	3	1
BLOOD_Myeloma	SLURP1 →	+0.053	+4.807	<.001	.006	3	1
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PAX1 by PLCL2 expression — BLOOD_Leukemia

Explore this box plot interactively →