PLCL1

Across TCGA pan-cancer cohorts, PLCL1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PLCL1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PLCL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PLCL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PLCL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.947	0.739	.002	30	view →
PDAC	OS	Quartile	All	0.715	0.413	.007	17	view →
HNSC	DFS	Tertile	IV	1.000	0.873	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PLCL1–CCRCC (OS)

Open the CCRCC breakdown →