PLCL1

Across TCGA patient cohorts, PLCL1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCL1-associated genes across cancer lineages are ASNS, ATM, and eEF2. Each is linked with PLCL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLCL1-to-partner and partner-to-PLCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PLCL1-low versus PLCL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCL1→partner) and Y-score (partner→PLCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.543	+2.330	.002	.020	3	4
COAD	ATM →	-0.435	-2.313	.013	.035	3	4
LUSC	eEF2 →	+0.146	+2.124	.042	.010	3	3
LUSC	TFRC →	+0.570	+1.594	.035	.043	3	3
UCEC	C-Raf →	+0.090	+1.099	.020	.016	3	3
UCEC	Cyclin-B1 →	+0.513	+2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

ASNS by PLCL1 expression — COAD

Explore this box plot interactively →