PLCL1

Across TCGA cell cohorts, PLCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,891 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLCL1-associated GO terms across cancer lineages are Protein K48-linked ubiquitination, Regulation of macroautophagy, and Endosome organization. Each is linked with PLCL1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLCL1-to-partner and partner-to-PLCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K48-linked ubiquitination grouped by PLCL1-low versus PLCL1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCL1→partner) and Y-score (partner→PLCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein K48-linked ubiquitination →	+0.044	+0.216	.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.084	+0.232	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Endosome organization →	+0.060	+0.260	.001	.001	3	7
LUNG_NSCLC_LUSC	Regulation of response to endoplasmic reticulum stress →	+0.083	+0.191	<.001	.002	2	7
BONE	Response to endoplasmic reticulum stress →	+0.057	+0.588	.001	.009	3	6
UPPER_AERODIGESTIVE_TRACT	Vesicle budding from membrane →	+0.076	+0.324	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,891 associations by consensus.

Protein K48-linked ubiquitination by PLCL1 expression — UPPER_AERODIGESTIVE_TRACT

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