PLCL1

Across TCGA cell cohorts, PLCL1 mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCL1-associated genes across cancer lineages are VWA3B, TAAR8, and OR52N1. Each is linked with PLCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCL1-to-partner and partner-to-PLCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWA3B grouped by PLCL1-low versus PLCL1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCL1→partner) and Y-score (partner→PLCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	VWA3B →	+0.020	+4.285	.007	.003	3	2
UPPER_AERODIGESTIVE_TRACT	TAAR8 →	+0.082	+4.357	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR52N1 →	+0.058	+2.959	<.001	.004	3	2
LUNG_NSCLC_LUAD	OR52L1 →	+0.068	+3.362	<.001	.001	3	2
LUNG_NSCLC_LUSC	SLC6A19 →	+0.050	+3.807	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	SIGLEC8 →	+0.090	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

VWA3B by PLCL1 expression — BLOOD_Myeloma

Explore this box plot interactively →