PLCL1

Across TCGA cell cohorts, PLCL1 mutation is significantly associated with the mutation status of many other genes, with 5,375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCL1-associated genes across cancer lineages are DIAPH1, RELN, and CSMD2. Each is linked with PLCL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLCL1-to-partner and partner-to-PLCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIAPH1 grouped by PLCL1-low versus PLCL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCL1→partner) and Y-score (partner→PLCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DIAPH1 →	+5.044	+5.614	.003	.003	1	6
OVARY	RELN →	+2.421	+3.376	.002	.002	1	6
LUNG_NSCLC_LUSC	CSMD2 →	+2.678	+3.652	.006	.006	1	5
CNS	RAI14 →	+4.459	+5.277	.005	.005	1	5
OVARY	CNTN6 →	+3.836	+4.204	<.001	<.001	1	5
BLOOD_Leukemia	NFASC →	+3.465	+3.913	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,375 associations by consensus.

DIAPH1 by PLCL1 expression — CNS

Explore this box plot interactively →