PLCH2

Across TCGA patient cohorts, PLCH2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,439 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PLCH2-associated genes across cancer lineages are CHPT1, AVPI1, and INPP1. Each is linked with PLCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCH2-to-partner and partner-to-PLCH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLCH2 versus CHPT1 in HNSC, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH2→partner) and Y-score (partner→PLCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHPT1 →	-0.679	-0.387	<.001	<.001	3	3
HNSC	AVPI1 →	+0.890	+0.481	<.001	.001	3	3
HNSC	INPP1 →	+0.552	+0.343	<.001	<.001	3	3
HNSC	TPRG1L →	+0.524	+0.535	<.001	<.001	3	3
LSCC	S1PR5 →	+0.996	+0.513	<.001	<.001	3	3
BRCA	RHBDL2 →	+0.870	+0.544	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,439 associations by consensus.

PLCH2 vs CHPT1 — HNSC

Explore this scatter interactively →