PLCH2

Across TCGA patient cohorts, PLCH2 mutation is significantly associated with the RNA expression of many other genes, with 4,954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCH2-associated genes across cancer lineages are RN7SL149P, RNU7-124P, and DAD1. Each is linked with PLCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCH2-to-partner and partner-to-PLCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL149P grouped by PLCH2-low versus PLCH2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH2→partner) and Y-score (partner→PLCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL149P →	+0.814	+2.495	<.001	.008	3	3
COAD	RNU7-124P →	+0.973	+2.499	<.001	.004	3	3
UCEC	DAD1 →	+0.301	+2.447	.006	.001	3	3
LIHC	RN7SL96P →	+0.127	+4.894	<.001	.004	3	3
SKCM	MED8 →	+0.385	+3.063	<.001	<.001	3	3
UCEC	YRDC →	+0.388	+1.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,954 associations by consensus.

RN7SL149P by PLCH2 expression — COAD

Explore this box plot interactively →