PLCH2

Across TCGA patient cohorts, PLCH2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCH2-associated genes across cancer lineages are ATM, PRDX1, and EGFR_pY1068. Each is linked with PLCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCH2-to-partner and partner-to-PLCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PLCH2-low versus PLCH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH2→partner) and Y-score (partner→PLCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.535	-3.000	<.001	<.001	3	3
UCEC	PRDX1 →	+0.192	+1.906	.004	.014	3	2
UCEC	EGFR_pY1068 →	-0.264	-2.643	.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.312	+1.916	.003	.009	3	2
UCEC	Annexin-1 →	+0.588	+1.785	<.001	.007	3	2
UCEC	TFRC →	+0.435	+2.321	.013	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by PLCH2 expression — UCEC

Explore this box plot interactively →