PLCH2

Across TCGA cell cohorts, PLCH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,323 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLCH2-associated GO terms across cancer lineages are Positive regulation of nucleocytoplasmic transport, Regulation of Notch signaling pathway, and Positive regulation of toll-like receptor signaling pathway. Each is linked with PLCH2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLCH2-to-partner and partner-to-PLCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nucleocytoplasmic transport grouped by PLCH2-low versus PLCH2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH2→partner) and Y-score (partner→PLCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of nucleocytoplasmic transport →	+0.090	+2.672	.002	<.001	3	9
OESOPHAGUS	Regulation of Notch signaling pathway →	+0.086	+2.481	.001	.002	3	9
LUNG_NSCLC_LUAD	Positive regulation of toll-like receptor signaling pathway →	+0.082	+0.829	<.001	.006	3	8
STOMACH	Negative regulation of supramolecular fiber organization →	+0.102	+1.552	<.001	.001	3	8
URINARY_TRACT	Positive regulation of protein import into nucleus →	+0.158	+3.007	<.001	<.001	3	8
OESOPHAGUS	Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay →	+0.176	+2.014	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,323 associations by consensus.

Positive regulation of nucleocytoplasmic transport by PLCH2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →