PLCH2

Across TCGA cell cohorts, PLCH2 mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCH2-associated genes across cancer lineages are LCE2A, IZUMO1R, and GUCA2A. Each is linked with PLCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCH2-to-partner and partner-to-PLCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE2A grouped by PLCH2-low versus PLCH2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH2→partner) and Y-score (partner→PLCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LCE2A →	+0.060	+4.954	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	GUCA2A →	+0.065	+4.736	<.001	.009	3	2
LARGE_INTESTINE	SH3GL2 →	+1.116	+2.754	<.001	.001	3	2
OESOPHAGUS	IL26 →	+0.050	+4.158	<.001	<.001	3	1
OESOPHAGUS	OPCML →	+0.013	+3.115	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

LCE2A by PLCH2 expression — KIDNEY

Explore this box plot interactively →