PLCH1

Across TCGA patient cohorts, PLCH1 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCH1-associated genes across cancer lineages are GAPDH, eEF2, and ACC_pS79. Each is linked with PLCH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLCH1-to-partner and partner-to-PLCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PLCH1-low versus PLCH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH1→partner) and Y-score (partner→PLCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.590	+1.593	.002	.043	3	5
UCEC	eEF2 →	+0.237	+1.906	.018	.014	3	4
LUSC	ACC_pS79 →	+0.234	+1.892	.027	.027	3	3
LUAD	mTOR_pS2448 →	-0.257	-2.987	.014	.035	3	3
UCEC	p27_pT198 →	+0.088	+0.947	.003	.047	3	3
UCEC	ASNS →	+0.372	+1.523	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

GAPDH by PLCH1 expression — COAD

Explore this box plot interactively →