PLCH1

Across TCGA cell cohorts, PLCH1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCH1-associated genes across cancer lineages are OR13D1, MBD3L2B, and CLEC1B. Each is linked with PLCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCH1-to-partner and partner-to-PLCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by PLCH1-low versus PLCH1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCH1→partner) and Y-score (partner→PLCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR13D1 →	+0.032	+4.217	<.001	.005	3	2
STOMACH	MBD3L2B →	+0.032	+3.432	<.001	.008	3	2
BONE	CLEC1B →	+0.054	+4.000	<.001	.008	3	1
BONE	MDS2 →	+0.097	+4.000	<.001	.008	3	1
LUNG_NSCLC_LUSC	KRTAP19-1 →	+0.546	+3.137	.002	.003	3	1
LUNG_SCLC	CXorf21 →	+0.041	+3.796	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

OR13D1 by PLCH1 expression — URINARY_TRACT

Explore this box plot interactively →