PLCG1

Across TCGA patient cohorts, PLCG1 mutation is significantly associated with the RNA expression of many other genes, with 4,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCG1-associated genes across cancer lineages are MTHFD1, SHMT2, and TAF9. Each is linked with PLCG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLCG1-to-partner and partner-to-PLCG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD1 grouped by PLCG1-low versus PLCG1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCG1→partner) and Y-score (partner→PLCG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTHFD1 →	+0.466	+3.360	.004	.005	3	4
UCEC	SHMT2 →	+0.549	+2.606	<.001	<.001	3	4
UCEC	TAF9 →	+0.623	+2.415	<.001	<.001	3	3
UCEC	CCL4 →	+1.076	+2.168	<.001	<.001	3	3
UCEC	UHRF1 →	+0.964	+2.733	<.001	<.001	3	3
UCEC	CCL3 →	+0.859	+1.720	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,161 associations by consensus.

MTHFD1 by PLCG1 expression — SKCM

Explore this box plot interactively →