PLCG1

Across TCGA patient cohorts, PLCG1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCG1-associated genes across cancer lineages are PDCD4, ATM, and eEF2. Each is linked with PLCG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCG1-to-partner and partner-to-PLCG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PLCG1-low versus PLCG1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCG1→partner) and Y-score (partner→PLCG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.631	-3.000	.006	.036	3	3
UCEC	ATM →	-0.511	-3.000	<.001	<.001	3	3
COAD	eEF2 →	+0.607	+3.178	<.001	.010	3	2
COAD	Rictor →	-1.074	-3.161	.029	.019	3	2
UCEC	14-3-3_beta →	-0.094	-2.295	.003	.005	3	2
UCEC	eIF4E →	+0.158	+2.247	.018	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PDCD4 by PLCG1 expression — SKCM

Explore this box plot interactively →