PLCG1

Across TCGA cell cohorts, PLCG1 mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCG1-associated genes across cancer lineages are C16orf90, VWA5B1, and NXNL1. Each is linked with PLCG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCG1-to-partner and partner-to-PLCG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf90 grouped by PLCG1-low versus PLCG1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCG1→partner) and Y-score (partner→PLCG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
BLOOD_Leukemia	VWA5B1 →	+0.150	+3.189	.003	.002	3	1
BLOOD_Leukemia	NXNL1 →	+0.111	+3.304	<.001	.001	3	1
BLOOD_Leukemia	C5orf46 →	+0.061	+2.638	.004	.009	3	1
OVARY	USP17L13 →	+0.013	+5.807	<.001	.001	3	1
OVARY	USP17L17 →	+0.013	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

C16orf90 by PLCG1 expression — URINARY_TRACT

Explore this box plot interactively →