PLCD3

Across TCGA patient cohorts, PLCD3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCD3-associated genes across cancer lineages are p70-S6K_pT389, Chk2, and Di-Ras3. Each is linked with PLCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCD3-to-partner and partner-to-PLCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by PLCD3-low versus PLCD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD3→partner) and Y-score (partner→PLCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.173	-3.459	.017	.005	3	2
UCEC	Chk2 →	-0.192	-2.321	.032	.033	3	2
UCEC	Di-Ras3 →	-0.137	-2.571	.015	.010	3	2
SKCM	PKC-a_pS657 →	+0.448	+3.000	.043	.036	3	1
SKCM	PKC-a →	+0.538	+3.000	.020	.036	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.463	+2.087	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

p70-S6K_pT389 by PLCD3 expression — UCEC

Explore this box plot interactively →