PLCD3

Across TCGA cell cohorts, PLCD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,929 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLCD3-associated GO terms across cancer lineages are Protein localization to membrane, Positive regulation of protein localization to membrane, and Regulation of plasma membrane repair. Each is linked with PLCD3 in more than 11 cancer types. Because this analysis shows association rather than direction, both PLCD3-to-partner and partner-to-PLCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to membrane grouped by PLCD3-low versus PLCD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD3→partner) and Y-score (partner→PLCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to membrane →	+0.080	+1.392	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of protein localization to membrane →	+0.121	+2.019	<.001	<.001	3	12
BONE	Regulation of plasma membrane repair →	+0.317	+1.070	<.001	<.001	3	11
BLOOD_Lymphoma	Positive regulation of plasma membrane repair →	+0.317	+0.918	.001	.002	3	11
LIVER	Positive regulation of protein localization to plasma membrane →	+0.101	+1.198	.006	.006	3	11
BONE	Protein localization to cell periphery →	+0.069	+1.194	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,929 associations by consensus.

Protein localization to membrane by PLCD3 expression — BONE

Explore this box plot interactively →