PLCD3

Across TCGA cell cohorts, PLCD3 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCD3-associated genes across cancer lineages are PROP1, BHLHA9, and PHF5A. Each is linked with PLCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCD3-to-partner and partner-to-PLCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by PLCD3-low versus PLCD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD3→partner) and Y-score (partner→PLCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.027	+3.289	<.001	.009	3	2
KIDNEY	BHLHA9 →	+0.036	+5.000	<.001	.005	3	1
LARGE_INTESTINE	PHF5A →	+0.546	+3.502	.001	.001	3	1
LARGE_INTESTINE	TRMU →	+0.720	+3.502	<.001	.001	3	1
LARGE_INTESTINE	ZBED4 →	+0.545	+3.307	.003	.003	3	1
LARGE_INTESTINE	PFDN4 →	-0.580	-3.102	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

PROP1 by PLCD3 expression — BLOOD_Leukemia

Explore this box plot interactively →