Across TCGA patient cohorts, PLCD1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCD1-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Caspase-8. Each is linked with PLCD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCD1-to-partner and partner-to-PLCD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD1→partner) and Y-score (partner→PLCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.597	+2.019	.006	.017	3	3
UCEC	ATM →	-0.423	-1.847	.011	.008	3	2
UCEC	Caspase-8 →	-0.202	-3.558	.028	.002	3	2
UCEC	14-3-3_beta →	-0.079	-1.973	.031	.029	3	1
UCEC	ERK2 →	+0.160	+1.807	.023	.025	3	1
UCEC	ACC1 →	+0.328	+3.183	.014	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

PLCD1 survival (RNA) · tumor vs normal (RNA) · all PLCD1 data types