Across TCGA cell cohorts, PLCD1 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCD1-associated genes across cancer lineages are CT45A6, OR8B4, and SLC10A2. Each is linked with PLCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCD1-to-partner and partner-to-PLCD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD1→partner) and Y-score (partner→PLCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CT45A6 →	+0.099	+4.906	<.001	.006	3	1
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
SKIN	SLC10A2 →	+0.004	+4.437	<.001	.004	3	1
SKIN	TARM1 →	+0.724	+4.437	<.001	.004	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
BLOOD_Lymphoma	HOXB1 →	+0.007	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

Exploration

PLCD1 survival (RNA) · tumor vs normal (RNA) · all PLCD1 data types