PLCB4

Across TCGA patient cohorts, PLCB4 mutation is significantly associated with the RNA expression of many other genes, with 5,212 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PLCB4-associated genes across cancer lineages are DCLRE1B, MRPL37, and PSMC3IP. Each is linked with PLCB4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLCB4-to-partner and partner-to-PLCB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCLRE1B grouped by PLCB4-low versus PLCB4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB4→partner) and Y-score (partner→PLCB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DCLRE1B →	+0.429	+2.619	<.001	.005	3	6
LUAD	MRPL37 →	+0.421	+2.877	<.001	.001	3	5
LUAD	PSMC3IP →	+0.575	+2.011	<.001	.001	3	5
UCEC	YARS1 →	+0.445	+1.638	<.001	<.001	3	5
LUAD	BIRC5 →	+0.899	+1.930	.001	.008	3	5
LUAD	SF3A1 →	+0.395	+2.735	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,212 associations by consensus.

DCLRE1B by PLCB4 expression — LUAD

Explore this box plot interactively →