PLCB4

Across TCGA patient cohorts, PLCB4 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCB4-associated genes across cancer lineages are mTOR_pS2448, Cyclin-B1, and c-Kit. Each is linked with PLCB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCB4-to-partner and partner-to-PLCB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PLCB4-low versus PLCB4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB4→partner) and Y-score (partner→PLCB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	mTOR_pS2448 →	-0.172	-1.700	.026	.043	3	3
LUAD	Cyclin-B1 →	+0.804	+2.906	<.001	.001	3	3
SKCM	c-Kit →	-0.327	-0.815	.029	.014	3	3
COAD	ASNS →	+0.705	+2.178	<.001	.035	3	3
LUAD	FoxM1 →	+0.444	+2.906	<.001	.001	3	2
LUAD	PAI-1 →	+0.916	+2.459	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

mTOR_pS2448 by PLCB4 expression — LUAD

Explore this box plot interactively →