PLCB4

Across TCGA cell cohorts, PLCB4 mutation is significantly associated with the RNA expression of many other genes, with 1,048 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCB4-associated genes across cancer lineages are BCL2L12, MAP3K6, and NUDC. Each is linked with PLCB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCB4-to-partner and partner-to-PLCB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCL2L12 grouped by PLCB4-low versus PLCB4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB4→partner) and Y-score (partner→PLCB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BCL2L12 →	+0.563	+3.169	.001	.006	3	2
SKIN	MAP3K6 →	+0.582	+3.252	.006	.002	3	2
LARGE_INTESTINE	NUDC →	+0.440	+2.404	.004	.004	3	2
UPPER_AERODIGESTIVE_TRACT	CT45A7 →	+0.069	+4.209	<.001	.006	3	2
LUNG_SCLC	AADACL4 →	+0.090	+3.817	<.001	.004	3	2
CNS	OR56A5 →	+0.017	+4.035	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,048 associations by consensus.

BCL2L12 by PLCB4 expression — SKIN

Explore this box plot interactively →