PLCB4

Across TCGA cell cohorts, PLCB4 mutation is significantly associated with the mutation status of many other genes, with 7,526 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCB4-associated genes across cancer lineages are DDR2, CNOT6L, and SCG2. Each is linked with PLCB4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLCB4-to-partner and partner-to-PLCB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDR2 grouped by PLCB4-low versus PLCB4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB4→partner) and Y-score (partner→PLCB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DDR2 →	+3.078	+2.944	.003	.003	1	6
UPPER_AERODIGESTIVE_TRACT	CNOT6L →	+4.954	+4.392	.008	.008	1	6
BREAST	SCG2 →	+5.297	+5.297	.004	.004	1	6
LARGE_INTESTINE	LRRC7 →	+1.568	+1.965	.002	.002	1	6
SKIN	SPTBN2 →	+3.062	+2.259	.001	.001	1	6
LARGE_INTESTINE	PREX1 →	+2.831	+2.681	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,526 associations by consensus.

DDR2 by PLCB4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →