PLCB3

Across TCGA patient cohorts, PLCB3 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCB3-associated genes across cancer lineages are 4E-BP1, Bak, and Annexin-1. Each is linked with PLCB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLCB3-to-partner and partner-to-PLCB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PLCB3-low versus PLCB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB3→partner) and Y-score (partner→PLCB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.432	+3.169	.003	.018	3	3
UCEC	Bak →	+0.198	+1.502	.012	.025	3	3
UCEC	Annexin-1 →	+0.768	+2.432	<.001	<.001	3	3
UCEC	CDK1 →	+0.125	+1.598	.008	.040	3	3
STAD	eIF4E →	+0.247	+3.169	.005	.019	1	4
STAD	FoxM1 →	+0.285	+3.169	.027	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

4E-BP1 by PLCB3 expression — STAD

Explore this box plot interactively →