PLCB3

Across TCGA cell cohorts, PLCB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,838 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLCB3-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Regulation of centriole-centriole cohesion, and Mitotic chromosome condensation. Each is linked with PLCB3 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLCB3-to-partner and partner-to-PLCB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by PLCB3-low versus PLCB3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB3→partner) and Y-score (partner→PLCB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	mRNA alternative polyadenylation →	+0.086	+0.746	<.001	.001	3	13
BONE	Regulation of centriole-centriole cohesion →	+0.172	+1.098	<.001	<.001	3	12
BONE	Mitotic chromosome condensation →	+0.150	+0.876	.007	<.001	3	12
BONE	RNA export from nucleus →	+0.108	+0.831	<.001	<.001	3	11
BONE	Establishment of spindle orientation →	+0.102	+0.724	<.001	<.001	3	11
BONE	Metaphase/anaphase transition of mitotic cell cycle →	+0.177	+0.924	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,838 associations by consensus.

mRNA alternative polyadenylation by PLCB3 expression — BONE

Explore this box plot interactively →