PLCB3

Across TCGA cell cohorts, PLCB3 mutation is significantly associated with the RNA expression of many other genes, with 386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCB3-associated genes across cancer lineages are DPPA3, CD2, and UBE3A. Each is linked with PLCB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCB3-to-partner and partner-to-PLCB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA3 grouped by PLCB3-low versus PLCB3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB3→partner) and Y-score (partner→PLCB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DPPA3 →	+0.046	+4.273	<.001	.006	3	2
LUNG_NSCLC_LUAD	CD2 →	+0.036	+3.518	.001	.008	3	2
LARGE_INTESTINE	UBE3A →	+0.508	+2.158	.002	.004	3	2
LARGE_INTESTINE	SCN2A →	+0.339	+3.321	<.001	.004	3	2
LARGE_INTESTINE	ZNF18 →	+0.454	+2.158	.005	.004	3	2
LARGE_INTESTINE	SGCB →	+1.021	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 386 associations by consensus.

DPPA3 by PLCB3 expression — SKIN

Explore this box plot interactively →