PLCB2

Across TCGA patient cohorts, PLCB2 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,210 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLCB2-associated proteins across cancer lineages are ARHGAP45, WAS, and WDFY4. Each is linked with PLCB2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLCB2-to-partner and partner-to-PLCB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLCB2 versus ARHGAP45 in GBM, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB2→partner) and Y-score (partner→PLCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.676	+0.839	<.001	<.001	3	10
GBM	WAS →	+0.721	+1.049	<.001	<.001	3	10
GBM	WDFY4 →	+0.590	+1.069	<.001	<.001	3	10
OV	ARHGAP25 →	+1.067	+1.039	.005	.001	3	10
OV	CORO1A →	+0.752	+0.920	<.001	<.001	3	10
BRCA	COTL1 →	+0.664	+0.985	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,210 associations by consensus.

PLCB2 vs ARHGAP45 — GBM

Explore this scatter interactively →