PLCB2

Across TCGA patient cohorts, PLCB2 protein abundance is significantly associated with the RNA expression of many other genes, with 19,784 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLCB2-associated genes across cancer lineages are SIRPB1, TLR8, and LILRA1. Each is linked with PLCB2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLCB2-to-partner and partner-to-PLCB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLCB2 versus SIRPB1 in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB2→partner) and Y-score (partner→PLCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SIRPB1 →	+0.887	+0.485	<.001	<.001	3	10
GBM	TLR8 →	+1.203	+0.645	<.001	<.001	3	10
GBM	LILRA1 →	+0.716	+0.539	<.001	<.001	3	10
OV	CPVL →	+1.409	+0.415	<.001	<.001	3	10
GBM	BTK →	+1.073	+0.733	<.001	<.001	3	10
GBM	ABI3 →	+1.137	+0.704	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,784 associations by consensus.

PLCB2 vs SIRPB1 — HNSC

Explore this scatter interactively →