PLCB2

Across TCGA patient cohorts, PLCB2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCB2-associated genes across cancer lineages are Di-Ras3, YAP, and eIF4E. Each is linked with PLCB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCB2-to-partner and partner-to-PLCB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by PLCB2-low versus PLCB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB2→partner) and Y-score (partner→PLCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.166	-2.893	<.001	.001	3	3
LUSC	YAP →	-0.228	-3.000	.020	.035	3	2
UCEC	eIF4E →	+0.153	+1.716	.025	.003	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.375	+1.459	.023	.012	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.411	-1.446	.004	.012	3	2
UCEC	PREX1 →	-0.196	-1.700	.027	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Di-Ras3 by PLCB2 expression — UCEC

Explore this box plot interactively →