PLCB2

Across TCGA cell cohorts, PLCB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,478 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLCB2-associated GO terms across cancer lineages are Purine nucleotide biosynthetic process, RNA localization to Cajal body, and RNA localization to nucleus. Each is linked with PLCB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLCB2-to-partner and partner-to-PLCB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine nucleotide biosynthetic process grouped by PLCB2-low versus PLCB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB2→partner) and Y-score (partner→PLCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Purine nucleotide biosynthetic process →	+0.081	+2.435	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	RNA localization to Cajal body →	+0.074	+0.696	<.001	.007	2	8
UPPER_AERODIGESTIVE_TRACT	RNA localization to nucleus →	+0.074	+0.696	<.001	.007	2	8
BONE	Lipid catabolic process →	-0.056	-2.080	<.001	.005	3	7
BONE	Regulation of mRNA processing →	+0.085	+1.998	.005	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Formation of cytoplasmic translation initiation complex →	+0.099	+0.733	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,478 associations by consensus.

Purine nucleotide biosynthetic process by PLCB2 expression — BONE

Explore this box plot interactively →