PLCB1

Across TCGA patient cohorts, PLCB1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCB1-associated genes across cancer lineages are INPP4B, C-Raf, and FoxM1. Each is linked with PLCB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLCB1-to-partner and partner-to-PLCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PLCB1-low versus PLCB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB1→partner) and Y-score (partner→PLCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	INPP4B →	-0.291	-1.305	.032	.028	3	4
UCEC	C-Raf →	+0.138	+1.847	.001	.007	3	3
LUSC	FoxM1 →	+0.315	+1.709	.003	.026	3	3
UCEC	4E-BP1 →	+0.378	+4.169	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.657	+4.087	<.001	<.001	3	3
UCEC	ASNS →	+0.448	+1.514	<.001	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

INPP4B by PLCB1 expression — LUAD

Explore this box plot interactively →