PLCB1

Across TCGA cell cohorts, PLCB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,005 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLCB1-associated GO terms across cancer lineages are Activation of meiosis, Interleukin-12-mediated signaling pathway, and Phosphatidylinositol catabolic process. Each is linked with PLCB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both PLCB1-to-partner and partner-to-PLCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Activation of meiosis grouped by PLCB1-low versus PLCB1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB1→partner) and Y-score (partner→PLCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Activation of meiosis →	+1.595	+2.528	<.001	<.001	3	16
BONE	Interleukin-12-mediated signaling pathway →	-0.209	-2.036	<.001	<.001	3	12
URINARY_TRACT	Phosphatidylinositol catabolic process →	+1.052	+1.482	.002	<.001	2	13
LIVER	Regulation of acrosome reaction →	+1.899	+2.690	<.001	<.001	3	12
OVARY	Egg activation →	-0.299	-1.724	<.001	<.001	3	11
STOMACH	Positive regulation of acrosome reaction →	+1.465	+2.192	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,005 associations by consensus.

Activation of meiosis by PLCB1 expression — LUNG_NSCLC_LUSC

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