PLBD2

Across TCGA patient cohorts, PLBD2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLBD2-associated genes across cancer lineages are EGFR_pY1068, Ku80, and p62 Lck ligand. Each is linked with PLBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLBD2-to-partner and partner-to-PLBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PLBD2-low versus PLBD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLBD2→partner) and Y-score (partner→PLBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.281	-3.584	.020	.002	3	1
UCEC	Ku80 →	+0.274	+2.472	.016	.011	3	1
UCEC	p62 Lck ligand →	+0.398	+3.584	.011	.002	3	1
UCEC	Rad50 →	-0.294	-2.459	.012	.020	3	1
UCEC	STAT3_pY705 →	-0.303	-2.999	.016	.035	3	1
UCEC	Caspase-8 →	-0.271	-3.143	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by PLBD2 expression — UCEC

Explore this box plot interactively →