PLBD1

Across TCGA patient cohorts, PLBD1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLBD1-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and A-Raf_pS299. Each is linked with PLBD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLBD1-to-partner and partner-to-PLBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PLBD1-low versus PLBD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLBD1→partner) and Y-score (partner→PLBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.304	-1.906	.003	.016	3	2
UCEC	EGFR_pY1068 →	-0.234	-1.906	.020	.016	3	1
UCEC	A-Raf_pS299 →	-0.172	-2.000	<.001	.030	3	1
UCEC	FoxM1 →	+0.259	+2.415	.012	.003	3	1
UCEC	Gab2 →	+0.283	+1.906	.049	.016	3	1
UCEC	INPP4B →	-0.299	-2.000	.021	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

STAT3_pY705 by PLBD1 expression — UCEC

Explore this box plot interactively →