PLBD1

Across TCGA cell cohorts, PLBD1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLBD1-associated genes across cancer lineages are IDI2, OR10AG1, and PABPC1L2A. Each is linked with PLBD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLBD1-to-partner and partner-to-PLBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by PLBD1-low versus PLBD1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLBD1→partner) and Y-score (partner→PLBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IDI2 →	+0.023	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR14A2 →	+0.022	+5.228	<.001	.005	3	1
LARGE_INTESTINE	USP14 →	+0.720	+3.087	.003	.006	3	1
LARGE_INTESTINE	HSPD1 →	+0.679	+3.125	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

IDI2 by PLBD1 expression — OVARY

Explore this box plot interactively →