PLBD1

Across TCGA cell cohorts, PLBD1 mutation is significantly associated with the mutation status of many other genes, with 4,977 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLBD1-associated genes across cancer lineages are CYFIP1, TPP2, and SCNN1B. Each is linked with PLBD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLBD1-to-partner and partner-to-PLBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYFIP1 grouped by PLBD1-low versus PLBD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLBD1→partner) and Y-score (partner→PLBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYFIP1 →	+2.994	+4.977	<.001	<.001	1	4
SKIN	TPP2 →	+4.824	+5.392	.004	.004	1	3
SKIN	SCNN1B →	+4.239	+5.053	.007	.007	1	3
LUNG_NSCLC_LUAD	ZNF646 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	MTA1 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	GSAP →	+4.772	+5.339	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,977 associations by consensus.

CYFIP1 by PLBD1 expression — LARGE_INTESTINE

Explore this box plot interactively →