PLB1

Across TCGA patient cohorts, PLB1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLB1-associated genes across cancer lineages are PCNA, Cyclin-B1, and ATM. Each is linked with PLB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLB1-to-partner and partner-to-PLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PLB1-low versus PLB1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLB1→partner) and Y-score (partner→PLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.386	+3.008	.002	.019	2	4
UCEC	Cyclin-B1 →	+0.443	+1.378	.008	.008	3	3
UCEC	ATM →	-0.491	-2.662	<.001	<.001	3	3
SKCM	ER-alpha →	-0.112	-1.184	.043	.020	3	2
COAD	Caveolin-1 →	-0.897	-2.991	.015	.036	3	2
COAD	4E-BP1_pT70 →	+0.125	+3.008	.045	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by PLB1 expression — COAD

Explore this box plot interactively →