PLB1

Across TCGA cell cohorts, PLB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,281 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLB1-associated GO terms across cancer lineages are Negative regulation of defense response, Rho protein signal transduction, and Positive regulation of protein localization to nucleus. Each is linked with PLB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLB1-to-partner and partner-to-PLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of defense response grouped by PLB1-low versus PLB1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLB1→partner) and Y-score (partner→PLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of defense response →	+0.076	+0.816	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.125	+0.542	<.001	<.001	3	10
PANCREAS	Positive regulation of protein localization to nucleus →	+0.102	+0.938	<.001	<.001	3	10
SOFT_TISSUE	Energy derivation by oxidation of organic compounds →	+0.067	+0.433	<.001	<.001	3	10
BONE	Viral process →	+0.130	+0.983	<.001	.001	3	10
OESOPHAGUS	Mitochondrial electron transport, cytochrome c to oxygen →	+0.112	+0.700	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,281 associations by consensus.

Negative regulation of defense response by PLB1 expression — BREAST

Explore this box plot interactively →