PLB1

Across TCGA cell cohorts, PLB1 mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLB1-associated genes across cancer lineages are DPH5, OR2J2, and OR2T35. Each is linked with PLB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLB1-to-partner and partner-to-PLB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPH5 grouped by PLB1-low versus PLB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLB1→partner) and Y-score (partner→PLB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DPH5 →	+0.603	+3.502	.001	.001	3	2
CNS	OR2J2 →	+0.026	+4.981	<.001	.008	3	2
BLOOD_Myeloma	OR2T35 →	+0.086	+4.807	<.001	.006	3	1
SOFT_TISSUE	LCE2B →	+0.040	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	PPIAL4F →	+0.059	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

DPH5 by PLB1 expression — LARGE_INTESTINE

Explore this box plot interactively →