PLAUR

Across TCGA pan-cancer cohorts, PLAUR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLAUR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PLAUR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLAUR is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where PLAUR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAUR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+3.338	<.001	11	view →
HNSC	Male	III,IV	+2.350	<.001	11	view →
KIRC	Male	IV	+2.078	<.001	11	view →
COAD	All	IV	+1.302	<.001	11	view →
STAD	Male	II,III,IV	+2.005	<.001	8	view →
KIRP	Male	All	+1.353	<.001	7	view →
BRCA	All	All	+1.463	<.001	6	view →
UCEC	All	All	+1.025	.003	6	view →
LUAD	Female	II,III,IV	+0.924	<.001	6	view →
ESCA	All	All	+3.023	<.001	3	view →
CHOL	All	All	+2.435	<.001	3	view →
KICH	All	II,III,IV	−1.219	.022	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLAUR–THCA

Open the THCA breakdown →